Jane Vasko is a New York City street cop who gets recruited by the FBI to infiltrate a major NYC drug and human trafficking ring. In a near death experience, Jane develops exceptional regenerative abilities that give her a unique indestructible advantage. With nothing to live for and no way to die, Painkiller Jane becomes an unstoppable force of nature seeking revenge to those who destroyed her life as she leaves a path of death and destruction in her wake.

劳模姐杰西卡·查斯坦加盟科幻新片《魔女狂花》。本片根据漫画改编，讲述查斯坦饰演的卧底女警在遭受重伤后意外获得超能力，并化身义警“止痛剂”，打击城市中的罪恶势力。查斯坦执掌的雀斑影业负责制作，此次是劳模姐继《他和她的孤独情事》和《动物园长的夫人》后再次担任制片人。