The name of painter Jean-Honore Fragonard (1732-1806) is synonymous for a kind of painting style which celebrates carefree romantic life, indoors and out. He was a painter during the final decades of the French monarchy. In this story, he and his brother Cyprien (Robin Renucci), who is an early pioneer in medical anatomy (he dissected corpses and made drawings of what he found in them), have fallen in love with the same woman, Marianne (Philippine Leroy-Beaulieu), a laundress. This attraction has not escaped the notice of Salmon d'Anglas (Sami Frey), a conniving nobleman, who has his heart set on getting revenge on Jean-Honore (Joachim de Almeida) for refusing his patronage and becoming the darling of the French court.

Le célèbre peintre Jean-Honoré Fragonard tombe amoureux de son modèle, Marianne, également convoitée par un anatomiste.