Richmond Trinity Hospital's chief nursing officer Christina Hawthorne tries to stop an end-stage cancer patient's attempt at suicide.

A patient with dementia believes Christina is his wife.

Christina tries to save a Korean woman and her little boy after a car accident; Bobbie helps a young woman on the verge of losing her arm because of gangrene.

Christina squares off with an arrogant surgeon who is working on the case of a young heart patient she is caring for. Elsewhere, Ray works as Christina's mother-in-law's personal nurse, who, unknown by Christina, has been hospitalized. Kelly tends to a man with a worried wife.

Christina and the crew are hit with an onrush of new patients when another Richmond emergency room shuts down. One patient is recognized by Camille as an old friend from school who appears to have a drug problem. And a reporter wants to use Ray as an inside source for a revealing article she wants to write concerning the ER.

Christina gets trapped into working an overnight shift and finds herself in the middle of a potential custody battle.

Christina treats a female patient who appears to have been abused by her boyfriend; Bobbie helps a patient with abdominal pains; Ray helps a young man facing the possibility of being paralyzed; Camille gets a driving lesson from Kelly.

Christina battles Morrissey after he asks her to lay off nurses due to budget cuts. Therefore, Kelly's job is on the line and she also encounters some problems with a doctor. This episode also features a terrible tragedy inside the ER.

David's cancer is back and Christina does her best to comfort him while looking to get him a new treatment. Kelly has difficulties when trying to say goodbye to a patient and Ray hears astonishing news from Candy.