After competing in and completing the reality show, Trackdown, the five contestants, Axel, Hawk, King, Lioness and Shark are offered jobs to test new and experimental vehicles for Mr Lee, Trackdown’s creator and president and founder of Lee Industries, a multi-billion dollar company. The five accept his offer, but when a dangerous criminal mastermind named Paine escapes from prison, Axel has personal interest into helping recapture him.

Lee, who is acting clingy and parental around the team, equips them with new gear and weaponry to test. At the same time Paine and his henchman Spydah seek to destroy the Landmark City dam. Axel also tells Lioness about his past with Paine.

The Alpha Teens move out of Lee’s R & D physicality and into an abandoned Aquatic Center. Meanwhile, due to a freak accident caused by Axel previously, Paine gains new powers that emit terrible pain through his body which he can transfer to those he touch. With these powers, Spydah and added help from the acrobatic Cannonball Bros., Paine goes to Lee Industries, seeking revenge on Axel Manning.

Paine learns of Nutronium, a chemical that can put an end to his constant pain. He and Spydah seek to steal it with the help of Albert, a dangerous muscle-laden criminal who uses a barbell for a weapon. In the heat of battle with the Alpha Teens, Paine unintentionally mutates Albert into the super-strong giant, Flesh.

The Alpha Teens, Lee and the building security board head of Landmark City become trapped in the yet to be opened Lee Plaza. The culprit, Silas Greene the building’s deranged architect, seeks revenge against Lee using the building’s security robots and other lethal functions to dispose of him.

The Alpha Teens accompany Hawk, who stars in the movie being filmed, "Radioactive Island", to an island that served as a military testing site. While King’s animalistic nature steals Hawk’s thunder, it also gets the attention of Recombo, a mad scientist who combines different species of animals into one.

When Shark skips out on a fancy party held by Lee on his yacht, he is captured by the villain, Eel. With various sea creatures under his mind-control, Eel sends his "pet" giant squid to sink Lee’s yacht.

At Christmas time, while the other Alpha Teen members are packing to visit their families, a lonely Axel thinks of his late father. He is attacked by Dragon, a ninja mercenary, who like Axel, is skilled in the Jo-Lan martial art.

Bogey, a rival of Hawk’s, gets under Hawk’s skin at an airshow. Later, Hawk and the other Alpha Teens are trained to fly Mr. Lee’s Hypersonic Stratojet, an aircraft Paine has every intention on stealing.

As Paine plots to steal plutonium from Landmark City’s nuclear power plant, Col. Richter of Landmark City’s law enforcement accuses (with strong video evidence) that Axel stole an armored car filled with money. At the same time, Axel’s father, Sebastian Manning, seems to be alive.

Paine steals cyborgs from one of Lee’s factories. Having Spydah duplicate their schematics and create more, Paine now controls his own cyborg army.

Paine unleashes a huge hurricane on Landmark City with the Atmospheric Modifier, a device made by Dr. Nimbus, whose family Paine is holding hostage.

King has his eyes set on winning the WWC World Title Belt under the guise as the wrestler Royal Rumble. Paine however, seeks the belt for his own dastardly schemes and hires the rhyming extortionist, Vinnie Rossi to stand in for an injured Flesh. During the WWC battle royal for the title, Vinnie’s lovesickness for Lioness could cost him the match and much more.

Lee introduces the Alpha Teens to the somewhat insecure teenage genius, Garrett. In another scheme to ease his own inner pain, Paine sends Flesh and Spydah to kidnap Dr. Evans, an expert in sound wave research and Garrett’s former professor at Landmark University.

After Spydah is fired by Paine for failing to get a crucial flash drive that was protected by the Alpha Teens, he intends to prove himself to his former boss.

After Lee’s Mecha Speeder and the crew of the cargo ship that held the vehicle go missing, the Alpha Teens are sent to investigate on Halloween night. What they find is a virtually lost portion of Landmark City filled with zombies. Their leader, Bonez soon make Hawk, Shark and Lioness part of their ranks.

After being stopped by the Alpha Teens once again, Paine enlists the aid of five extreme athletes to take them out once and for all.

Magness returns to Landmark City with her new biker boyfriend, D-Zel. She systematically causes problems for Landmark City, the Alpha Teens and her father, Paine. D-Zel experiences a change that makes him truly one with his bike.

When a corrupt cop falsely accuses the Alpha Teens of grand theft auto, they become fugitives of the law. Worse yet, Hawk and King are captured, arrested and sentenced to serve time in the same prison where some of the villains they busted were sent to.

After a meteorite temporary knocks out all power within Landmark City, Paine intends to steal it to make the city go through a much more permanent blackout. Also, Hawk poses as the leader of the Alpha Teens so he could impress reporter, Michelle Moreno.

Flesh and Spydah poison Axel with potent venom from a very toxic water spider. As Axel, who is using Jo-Lan to slow down the toxin’s deadly effects, is getting medical attention, Shark is put in charge of the team by Axel himself.

The mystical sword of Jo-Lan is stolen from the Landmark City museum by a group of ninjas and the Alpha Teens go all the way to Hong Kong to recover it. Dragon returns with interest in the sword, mysterious intentions and unsure alliances.

As the Alpha Teens finally discover where Paine’s base is located, Paine seeks to tunnel under Landmark City flood the city with lava. However, because of the intense heat of the lava, Paine forces Vinnie Rossi, now the monstrous concrete man, Mass to do the job, or else his mother will pay the price.

Now, without a base to call home, Paine seeks to use a remote that can control electronic devices to blackmail Landmark City into giving him enough money to rebuild. Lioness's cousin from Brazil, Eliza comes to visit and immediately has Hawk and Shark attracted to her. Axel and Garrett, stumble into a mysterious room of Lee Industries that is off limits to anyone but Lee himself.

A year after the potential death of his father due to a bomb created by Paine, a frustrated Axel seeks to put Paine out of commission for good, even if it means interfering with police business and splitting up the team. Lee creates a lizard-like creature called the "Axel Manning advanced enhancement".