Three bodies are discovered in a burned-out home in Scottsdale and a fourth family member is missing; investigators realize they have a triple homicide on their hands and embark on a decades-long manhunt.

A young woman vanishes, and her pastor may hold the key to her whereabouts.

Police find a family savagely murdered in their quiet suburban Oklahoma home, but when police find a victim still clinging to life and able to provide some answers, they launch a desperate search for the perpetrators before they can kill again.

In rural Kentucky, police receive a distressing call about the brutal killing of a family in their home. Authorities learn the victim's son is the sole survivor of the attack by a disgruntled ex-handyman, but his recollection of the murder doesn't add up.

In small-town upstate New York, a young mother loses her 5-year old son, who's battled a medical condition that has plagued him since birth; doctors claim his death is not from a natural cause, and investigators soon suspect foul play.