Dr. Kenzo Tenma, a leading neurosurgeon at the Dusseldorf Hospital has received massive acclaim for his successful surgery on a famous opera singer. However, he is burdened by guilt. Due to pressure from the director, he had operated on the opera singer on the night that he was supposed to operate on another man. As a result, when the director’s orders him to operate on the mayor, he decides to ignore the order and instead works on saving the life of a young boy, brought to the hospital from the scene of a serial homicide. However, the boy's twin sister, who was brought in with the boy, and who still suffers from shock, keeps repeating the words 'kill him'.

Things look brighter for Dr. Tenma, now that Dr. Heinemann is dead. His career takes off, and even Eva tries to win him back. But unfortunately, all that success has drawn the attention of Detective Lunge.

An old mercenary soldier named Hugo is interrogated by Lunge about a student of his, a doctor named Tenma.

Nina meets with an old friend and boss, Mister Rosso. The delightful old boss however, has a very dark past.

Nina confronts Muller, one of the two detectives responsible for the death of her foster parents, the Fortners. Muller discovers that his protege, Roberto, is actually working for Johan and is now tasked with killing Nina.

Richard's past and present situation is revealed. Johan continues to bond with the Schuwald family and his intention is revealed.

Dr. Reichwein reveals the true nature of Johan to Mr. Schuwald. Dr. Tenma gets ready to assassinate Johan. Lunge concludes that Dr. Tenma will kill Schuwald next. Lotte confronts Nina about Johan.

Suk is put under surveillance by the new commissioner. Together with Grimmer, Suk retrieves the tape and research papers from the deposit box. But their movements is watched by various sides.

Nina and Dieter enters the Red Rose Mansion, but Nina faints from her disturbing experience. And they end up in the care of a puppeteer name Lipsky.

Martin, a hired hand, is hired by General Wolf's ex-associates to ‘take care’ of Eva. But his emotions get in the way of his orders.

Capek tries to berate Johan for his actions and tells him that everything should be done according to Capek's plans but Johan simply disagrees and disappears. Capek realizes his hold on his organization is crumbling and has his men pick up Nina in Frankfurt. Eva accosts the young man who was introduced to Johan, Christof Sievernich, demanding answers.

As time passes, more people in Ruhenheim are being shot dead by mysterious people and each other. Both Grimmer and Lunge determine that the owner of a local hotel is Klaus Poppe, also known as Franz Bonaparta. After subduing a man who was giving weapons to everyone in the town, they obtain information that one of the ringleaders is in a second hotel.

Lunge confronts Roberto, one of the ringleaders, in a hotel room. Both are subsequently wounded in the fight. Nina and Gillen arrive in Ruhenheim where they find a house containing drawings of the two twins by Bonaparta. This triggers a final memory and the secret to Johan's madness and motives, his quest for true solitude, as well as forgiveness for his actions. Bonaparta accompanies Tenma on his quest to find and kill Johan.