Dr. Kenzo Tenma, a leading neurosurgeon at the Dusseldorf Hospital has received massive acclaim for his successful surgery on a famous opera singer. However, he is burdened by guilt. Due to pressure from the director, he had operated on the opera singer on the night that he was supposed to operate on another man. As a result, when the director’s orders him to operate on the mayor, he decides to ignore the order and instead works on saving the life of a young boy, brought to the hospital from the scene of a serial homicide. However, the boy's twin sister, who was brought in with the boy, and who still suffers from shock, keeps repeating the words 'kill him'.

Things look brighter for Dr. Tenma, now that Dr. Heinemann is dead. His career takes off, and even Eva tries to win him back. But unfortunately, all that success has drawn the attention of Detective Lunge.

Eva tries to threaten Dr. Tenma, unless he gets back with her, she would reveal to the police that the tie that was found at the scene of the crime is his!

Nina meets with an old friend and boss, Mister Rosso. The delightful old boss however, has a very dark past.

Lotte, Frank and Karl are drifting apart. Lotte meets Nina Fortner and they become friends. Dr. Tenma searches for a perfect spot to shoot Johan.

After the death of his seniors, Suk is left to re-investigate case from the very beginning. He gets information from the orphans about a meeting with Grimmer. His intention to arrest Grimmer takes a different turn however when he gets deeper into the investigation. The episode also reveals that there is more to the nameless lady at the bar than she lets on.

Dr. Tenma takes Verderman hostage in a desperate search for Eva. And Verderman's dark past is revealed.

Capek tries to berate Johan for his actions and tells him that everything should be done according to Capek's plans but Johan simply disagrees and disappears. Capek realizes his hold on his organization is crumbling and has his men pick up Nina in Frankfurt. Eva accosts the young man who was introduced to Johan, Christof Sievernich, demanding answers.

Lunge confronts Roberto, one of the ringleaders, in a hotel room. Both are subsequently wounded in the fight. Nina and Gillen arrive in Ruhenheim where they find a house containing drawings of the two twins by Bonaparta. This triggers a final memory and the secret to Johan's madness and motives, his quest for true solitude, as well as forgiveness for his actions. Bonaparta accompanies Tenma on his quest to find and kill Johan.

Bonaparta attempts to shoot Johan dead, but is gunned down by Roberto, who dies of his own injuries soon afterwards. With the massacre now over, authorities rush into the town and attempt to determine what happened. Just as an officer is about to arrest Dr. Tenma, an ambulance worker arrives asking for Tenma's assistance.