The price for disobeying Dr. Heinemann's orders to operate on the mayor is costly for Dr. Tenma. His career begins to plummet. The boy whom he saved finally awakens, but a horrible incident occurs soon after.

Things look brighter for Dr. Tenma, now that Dr. Heinemann is dead. His career takes off, and even Eva tries to win him back. But unfortunately, all that success has drawn the attention of Detective Lunge.

An old mercenary soldier named Hugo is interrogated by Lunge about a student of his, a doctor named Tenma.

Nina confronts Muller, one of the two detectives responsible for the death of her foster parents, the Fortners. Muller discovers that his protege, Roberto, is actually working for Johan and is now tasked with killing Nina.

In exchange for her life, Roberto tells Eva to confront Tenma, who is currently treating a mob boss at a country house. Eva is promptly wounded by Roberto when she is unable to complete her task but is saved by Tenma.

Suspecting foul play in Robert's 'accidental' death fall, Dr. Reichwen makes some discoveries in his investigations. But as he later realizes, his investigations may have put him in harms way.

Lunge, from the BKA, learns that Johan may indeed exist. Nina goes into regressive hypnosis to learn more about the picture book and her past. Mr. Schuwald has a message for Dr. Tenma and sends Karl to Dresden to pass it to him.

Nina's experience in Prague is a nightmare for her. Tenma and Grimmer meets with a top man in the Czechoslovakian STB. They are offered a deal which Grimmer refuses to accept.

Former patients of Eisler Memorial Hospital enlist the aid of Alfred Baul, a lawyer, to represent Tenma. Baul in turn asks for the assistance of Fritz Vardemann. Vardemann visits Tenma in prison, and agrees to take on the defense, but is then called to the hospital when his wife goes into labor with their first child. When Baul visits Tenma in prison, Tenma is shocked to see that Baul is Roberto. Roberto then says that Eva Heinemann will be his next target.

Tenma manages to find Martin. A drunken Eva spots Johan at a party. Martin receives his final orders from his boss but his feelings gets in the way. And Martin gets way over his head when he tries to investigate Johan and his disciple, and the truth about his past is revealed.

The Baby is killed by a prostitute, and his death sends shockwaves in Petr Capek's organization. Capek becomes paranoid as to who is loyal or not and accidentally kills one of his guards. He makes it to his cottage where Johan is waiting for him.

Nina confronts Johan who presents her with a story on what happened when many people were poisoned at the Mansion of Red Roses. Nina realizes that she was the one who witnessed these deaths, the shock of this revelation nearly drives her to suicide, but she is saved by Tenma. Capek is gunned down by members of his organization when they find out about the guard that Capek killed.

As time passes, more people in Ruhenheim are being shot dead by mysterious people and each other. Both Grimmer and Lunge determine that the owner of a local hotel is Klaus Poppe, also known as Franz Bonaparta. After subduing a man who was giving weapons to everyone in the town, they obtain information that one of the ringleaders is in a second hotel.

It has been some time since the tragic blood battle, and everyone is working hard to put their lives back to normal. Tenma finally locates a woman he has been searching for, and she reveals some startling information.