Sean and Beverly Lincoln are a happily married English couple who are also the creators of a hit British TV show. Their life seems complete... that is, until a hugely powerful and charismatic US television network president persuades them to move to Los Angeles and recreate their show for American television. Things begin to unravel as soon as Sean and Beverly arrive in L.A. It soon becomes clear that the network executive has never even seen their show. To make matters worse, he insists that they replace their brilliant lead actor, an erudite Royal Shakespeare veteran with... Matt LeBlanc!

Sean and Beverly are still reeling from the network's decision to cast Matt LeBlanc as the star of their show. But when they meet him at a swanky L.A. dinner party at Merc's house, Matt couldn't be more charming or flattering about their show. Unfortunately, over time the natural animosity between Matt and Beverly rises to the surface, and Beverly learns just how much you don't want the former Friend as an enemy.

Beverly can't stand Matt, and the feeling is mutual. As a result Sean and Matt end up spending more time together, including an extended adventure in Las Vegas. Soon the two guys have bonded, leaving Beverly feeling excluded by her husband's new bromance.

Sean and Beverly end up on all-night road trip with Matt when they pick him up from a bar.

Sean's infatuation with the lovely "Pucks!" actress Morning Randolph is given an opportunity to blossom when Matt invites the two of them to a charity benefit. Sean realizes that his attraction to her may be, in fact, mutual. Meanwhile, Beverly and Carol share a joint and commiserate about the men in their lives.

Convinced that Sean is having an affair with Morning, Beverly packs a bag and leaves, intending to head back to London. However, in her distress, she is unaware that she's driving on the left side of the road. Beverly doesn't realize her mistake until she has a head-on collision - a collision which leads her down a road with even more dire consequences.