Throttle, Modo and Vinnie...The Biker Mice from Mars...escape their planet as it it devastated by the fish faced plutarkians. Crashlanding in Chicago, the renegade rodents soon discover the Plutarkians next target: EARTH. Led by his supreme chessiness, Lawrence Limburger, and his devilish cohorts, Greasepit and the fiendish Dr. Karbunkle, the Plutarkians are already undermining the Windy City. It's tail whippin' time 'cause the baddest motorcycle mammajammers in the universe are riding to the rescue.

The Biker Mice have to work double time to clear their names and save the mayor before Chief of Police Greasepit catches them.

Limburger receives help from the Lugie Brothers, who are part of the Scum of the Universe. They must fumigate the city in an attempt to drive the citizens of Chicago out of town.

When Modo is covered in toxic substances, Limburger escapes with his bike. Modo does not want to rest while Charley and the guys rescue his bike.

Limburger hires Evil Eye Weevil to reign chaos on the town, causing mischief and mayhem and succeeds in driving the trio apart.

A mysterious female biker is in town, helping out the three mice, while Limburger accepts help from Corroder Cody, who will help him purloin crude oil.

The Biker Mice realize that Limburger is not the only evil character in town, when they attempt to stop a bank robbery. Vinnie must descend into the Pits to save his brothers from the Pit Boss.

Two of the Biker Mice are injured when a new gang arrived in town, and stole all the gas.

When Limburger disappears mysteriously, his unintentional replacements turn out to be increasingly more powerful and evil.

In order to steal all the steel from the town, Limburger offers Modo a new arm to work for him.

The Biker Mice must stop Limburger's plan to ruin not only Christmas, but winter too, and save an orphanage.

The Heavy Metal mouse that the mice despised on Mars, heads into Chicago, but with an all-new attitude.