While Lucrezia is head of the Vatican, Rodrigo Borgia continued his retreat. He tries to erase his feelings of love for Julia and her desire for her own daughter, now married to Alfonso di Calabria. But even away from all temptations, he struggles to get there. For his part, his daughter, a young woman who became regent seat with wisdom and moderation, qualities that are lacking in Cesare. The latter, still at war in Romagna, hopes to achieve with a little luck to defeat Catarina and all the enemies of the Borgia family ...

Lucrezia is in a delicate position with the return of Rodrigo Borgia. It reigns supreme and does not hesitate to be cruel to his enemies. Pope became a counselor with him, Lucrezia can neither impose his word, nor to stop the fears of her husband, which occurred with the arrival of Cesare in Rome. The son Borgia is carried by his desire for conquest. Fierce, he is ready for anything ...

Cesare's new mistress could trigger a diplomatic incident, and public allegations of debauchery are made against the Borgia family.

When one of his commanders captures a city without authorisation, Cesare must appease a ruler. Lucrezia's son suffers a potentially mortal fall.

While Rodrigo engages in delicate politics, Leonardo da Vinci offers Cesare a powerful weapon and murder visits the Borgia family.

Outside of Italy, rebellion stirs and the Cardinals fear they'll lose their power, while plans begin for Lucrezia's next marriage.

Cesare loses his lover and his daughter, leading to a painful defeat, and Lucrezia's betrothal becomes politically and emotionally complex.

Cesare's renegade generals mount a rebellion against him, while those close to Rodrigo conspire against him, all on the eve of Lucrezia's wedding.

Lucrezia meets her new family with mixed results, while at home a malaria outbreak has historic consequences for the Borgias.

Rodrigo's death sets chaos in motion on many fronts and forces Cesare to practice his most sophisticated politics yet as stakes are raised.

With a new pope crowned and order breaking down, Cesare finds himself with more and stronger enemies than ever.

Cesare stands trial for treason against the Holy See and the Ten Commandments, with his old friend Niccolo Machiavelli as prosecutor.

Cesare's ultimate judgment is realized while Lucrezia struggles to make sense of her family's history and its future.