Since his failure to save Jun, Shu is suffering traumatic memories of the Apocalypse Virus and hallucinating seeing people being infected which cost the Undertakers a mission to stop a convoy. Unwilling to join them anymore, Gai kicks Shu out the Undertakers. Retuning home, Shu finds Inori leaving but not before giving him her new song but he slaps it after getting another panic attack. Depressed, at school Shu ask Hare if he can be close to her but she slaps him as she isn't his replacement for Inori and he isn't the Shu that she loves and knows. Meanwhile, Major General Yan has put Shuichiro under house arrest for stealing the Apocalypse Virus meteorite and plans to have it transported overseas which Gai and Undertakers plan to attack the plane transporting the cargo and retrieve it. However, unknown to both the GHQ and the Undertakers, Seiga and the Anti Bodies have other plans and start vaccinating themselves. As Gai and his team get inside the transport plane, they find it empty and realize too late it is a trap. Seiga activates a genetic resonance broadcast at Tokyo Tower which causes the meteorite to spread the virus all over Tokyo and causing chaos. With both the GHQ and the Undertakers in disarray due to the virus, the Anti Bodies attack both of them and rescue Shuichiro from his confinement which Shuichiro watches the chaos from GHQ Headquarters and declares he will finish what he started 10 years ago.

While the virus is still spreading over Japan, Daryl arrives at the airport and kills everyone there in a rage of fury, including his own father Major General Yan. With the GHQ higherups gone, Shuichiro took over control of the entire military, and declares that the Funeral Parlor spreaded the disease as an act of terrorism. Meanwhile, after an call from Tsugumi, Shu finally regained control over himself. He then gathers Hare, Souta, Yahiro, Kanon, and Arisa, and explained to them that he wanted to go and rescue Gai and Inori. After witnessing Shu's power to draw out voids, the five students agreed to tag along. Back at the GHQ Headquarters, Haruka managed to escape from Shuichiro, but bumped into Inori and Gai. With Haruka's help, Inori was able to sing and broadcast her song "Departure" all over Japan. The song was able to reverse the effects of the Apocalypse Virus. At the same time, Shu and his friends arrives at the GHQ HQ, breaking through the barricades using different voids. When Shu finally reached Inori, a blond-haired boy appeared from behind and withdrew Inori's void, then sliced down on Shu. But Gai appeared and took the hit, saving Shu. The episode ends with Shu holding the unconscious Gai, while Shuichiro and Segai enters the Gate of Hell leading to Cocytus.

After Mana is completely resurrected, Mana greets Shu but is shunned by him after she speaks ill of Inori, much to her anger. Gai draws out Mana's Void to fight Shu while she triggers the Fourth Apocalypse, spreading the Apocalypse virus throughout the entire world. Haruka confronts Shuichiro who commits suicide by injecting the virus into himself. Meanwhile the Undertakers fight a group of Endlaves led by Daryl, who believes he changed because of them and wants to go back to his old self. Tsugumi finds that her attempts to hack the GHQ system are being repelled by another hacker as skilled as her. Shibungi figures that the hacker is actually Kenji and after tracking his location, he kills him, allowing Tsugumi to operate freely and help Ayase defeat Daryl. Just when Shu is about to be killed by Gai, Shu is seeing a flower while hearing the Voice of Inori.