Season 1 of La Blue Girl premiered on June 26, 1992.

La Blue Girl (four episodes, 1992–93) is an adaptation of the original manga. 18-year-old ninja in training Midou Miko is entrusted with the family business: making sure that sex-starved demons stay out of humanity's way! What does a ninja do? Fight, with every battle skill and sexual sorcery she can muster!

Shin Injuu Gakuen (two episodes, 1993) adapts the end of the manga, and as such is a follow-up and the conclusion to Miko's adventures in the first series. This time the enemies are Fubuki Kai, a rogue ninja who wants to defeat Miko and claim the title of best ninja, and the cybernetized survivors of the Suzuka clan.

Season 2 of La Blue Girl premiered on July 26, 1996.

Lady Blue (four episodes, 1996). Features an original story about two ghosts, Kyoshiro and Shanahime, harboring an old grudge against the Shikima and attacking several of Miko's friends.

19 year old ninja Midou Miko's fortune predicts that she's about to fall in love when an unexpected downpour throws her into the arms of 20 year old Hidemasa -whom she immediately recognizes as the man of her dreams!

Poor Miko must not only stave off the jealosy of her friend, 19 year-old Fubuki Kai, but is forced to put her fantasies on hold when she learns of the ancient and mysterious 'male' and 'female' flutes which are wreaking havoc on her parents and women on Earth. Suspecting that the new man in her life might know something about the flutes, she must enlist his aid, or perish!

Season 3 of La Blue Girl premiered on May 25, 2001.

La Blue Girl Returns (four episodes, 2001) is an anime series that continues the adventures of Miko Mido. Another original story, this time about the legendary Shikima Brain, a place rumored to bring total power over the universe. It is coveted by the insectoid ninja clan of the Mahoroba and protected by a mysterious clan, who may have a relation with Miko's previous life.

The plot begins when a race of butterfly-like demons named the Mahoroba want to enslave Miko Mido and her sister to steal the seal case that controls the Shikima. Their ultimate goal is to conquer the Shikima Brain, a legendary place of the Shikima realm which is said to confer the power to rule the universe.