The clinic's new nurse, Liam Smith, has a disastrous first day - and worst of all, he gets Dan's back up when he talks one of his patients out of getting rhinoplasty.

Keelin calls off her wedding to Ronan after an argument, while Cathy and Julia clash over Julia's bedside manner. Sinead is diagnosed with endometriosis and Dan collapses after a squash game.

Dan is devastated to discover he has a life-threatening and that the only operation that can cure him may also end his career. He tries to confide his problems to Cathy, but she tells him there is just too much water under the bridge now for them to be friends. Meanwhile, Keelin, with the help of her father, decides to follow Ronan to New York to give their relationship a second chance.

Clodagh makes the decision to reveal her true identity to her birth mother Carol. What Clodagh hasn't taken into account is whether or not the news will be well received.

Patrick refuses to take an agitated Conor for a session after Conor is rude and insults Bernie. Clodagh has had enough with her acupuncture patients and tells Julia she would like to concentrate on her general practice. Daisy is clearly uncomfortable around Jack and calls him a creep under her breath. Cathy is puzzled by the way Dan is acting and agrees to meet him for lunch. Liam teaches his son, Ian, a lesson after he had a few beers and fell over drunk. Ann Marie teases Jack about Clodagh fancying him but Jack tells her she has nothing to worry about.

Daisy thinks she may have been a cause of Conor's break up with his girlfriend, Siobhann, as well as his accident, after Siobhann warns Daisy to stay away from him. Cara tells Daisy that she didn't give Conor the wrong signals. Patrick reassures Daisy she's not to blame for what happened with Conor and needs to talk to him. Daisy talks to Conor and is relieved his self harming had nothing to do with her.

Dan is back with a second chance after surgery but his life is thrown into turmoil when he discovers Cathy is pregnant. It's a tumultuous start for the couple but they finally come together as one and look forward to their future. Cathy is now monitoring Clodagh's every step after her potentially life-threatening diagnosis and this causes tension for Clodagh. Daisy moves in with Conor and starts a relationship with Adam.

Liam dramatically kicks Cara out of the house when he finds out that she gave his son Ian's girlfriend Lucy the morning-after pill. Clodagh and Keelin are not on speaking terms because of Paul Dunne's legal action against Clodagh. Meanwhile, Cathy diagnosis Cara's friend Mary with clinical bulimia. Elsewhere, Aine is accused of taking petty cash causing her to step down as practice manager. Lorcan eventually finds out that the petty-cash culprit is actually his sister Alice who is back using again.

Daisy and Cara vie for the position of Practice Manager, while two suitors - Conor and Adam - compete for Daisy's affections. Meanwhile, Dan has an uncomfortable run-in with Emer - his nearly one-night stand - outside the Clinic and finds out that she is one of Lorcan's free-clinic patients. Elsewhere, Patrick asks Bernie to move in with him.

Cathy continues to lie in a coma after being run over by Niall Boylan unaware that she lost her cherished baby girl - Rachel - in the accident. Liam's son Ian is in trouble yet again and gets expelled from school and Liam has no choice but to put him into a fee paying school. Daisy returns home with Conor to be at Cathy's bedside and is there when Cathy suffers a brain haemorrhage and dies.

St. Matthew's Hospital Director Michael Kinsella is keen for Julia to take over the job but she declines and tells him she is happy at the Clarence Street Clinic but will she regret her decision when long standing patient of hers Elayne Sheridan discovers she is pregnant for the fourth time and places Julia in an unenviable dilemma. Meanwhiile, Dan continues his thirst for revenge on Niall Boylan through his wife, Aideen and discovers her love of art. Clodagh agrees to help out on the night clinic and the methadone bus and is moved by Lorcan's dedication to his ...

Ronan and Keelin's lives are turned upside down when a senseless attack on Ronan by one of Ian's friends leaves him potentially paralysed. Meanwhile, Liam's addiction begins to get worse and cracks begin to appear in Daisy and Conor's relationship as Daisy struggles to juggle her work with her home life. Elsewhere, Cara struggles with what she did to Hope and Kieran.

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