Rejser en nygift, britisk sygeplejerske, fra Anden Verdenskrig,tilbage i tiden til Skotland i 1743, hvor hun bliver kidnappet af Highlandere og tager sig af en såret, ung kriger.

Claire introduceres for godsejeren, men mistanken til hende vokser, da hun bliver ven med den mystiske Geillis Duncan, og klanen opdager hendes evner til at helbrede.

Claire bruger hendes medicinske evner til at flygte fra Leoch-slottet, og med hjælp fra Jamie, tager hun sig af et sygt barn.

Claire planlægger at flygte, under slottets samlings-ceremoni, men støder ind i Jamie og en fuld Dougal, og det ændrer hendes planer.

Claire tager sammen med Mackenzies ud på en tur, for at indsamle restancer og er vidne til at Dougal bruger Jamies ar, for at skaffe sympati for jakobitterne.

Claire bliver rasende, da hendes overraskelsesmøde med en britisk general bliver forstyrret af den farlige kaptajn Jack Randall, der mistænker hende for at holde på hemmeligheder.

Claire indgår i et tvangsægteskab med Jamie, men begynder hurtigt efter at få dybere følelser for ham.

Frank leder desperat efter sin forsvundne kone, imens Claire prøver at vænne sig til sit nye ægteskab. Claire bliver stillet overfor et følelsesmæssigt dilemma og en livsafgørende mulighed.

Jamie og højlænderne redder Claire fra Black Jack Randall.

Jamie håber at Hertugen af Sandringsham kan hjælpe ham med at få fjernet dusøren på hans hoved.

Claire og Geillis bliver anklaget for hekseri. Jamie lykkes at redde Claire, men ikke før hun opdager en hemmelighed omkring Geillis's fortid.

Jamie og Claire ankommer til Lallybroch for at overtage ansvaret af en ejendom som Jamie har arvet efter sin fars død.

Jamie befinder sig i et dilemma, da en Redcoat desertør fra hans fortid dukker op. Claire hjælper en fødende Jenny, imens Jamie og Ian tager med The Watch på et bagholdsangreb, hvilket får katastrofale konsekvenser.

Claire og Jenny tager uortodokse metoder i brug for at redde Jamie fra sine rød-jakkede gidseltagere.

Jamie afventer sin dødsdom i Wentworth fængsel, mens Claire og højlænderne desperat forsøger at komme på en rednings plan.

En plan bliver sat i værk for at forsøge at befri Jamie fra Wentworth fængslet, hvor han endnu en gang er havnet i kløerne på sin plageånd Black Jack Randall.

Returning to her own time, Claire must reconcile her future with the life she left behind. Shifting back to 18th century, Jamie, Claire and Murtagh arrive in France, but learn that Paris presents its own challenges.

Life in Paris is not without its trials as Jamie struggles to triumph over the traumas of his past. A fortunate meeting with Jacobite leader Prince Charles presents opportunities, while the Duke of Sandringham’s presence brings complications.

Jamie’s days and nights are dominated by political machinations, while Claire finds solace in her healing skills. As their plan to stop Culloden progresses, including engaging the aid of a young pickpocket, the past threatens to derail their forward momentum.

Claire and Jamie throw an elaborate dinner party intended to derail investors in Prince Charles’ war effort. Meanwhile, Claire’s revelation that Jack Randall is alive sparks Jamie in an unexpected way as he and Claire struggle to regain their physical intimacy.

Reunited, Jamie and Claire attempt to extinguish the fires their dinner party ignited; however, Claire is set off on an unexpected change of course. Jamie and Claire’s relationship is put to the ultimate test when the past rears its ugly head.

Jamie and Claire use Claire’s medical knowledge to devise a scheme to stop a wine deal which could fill the Prince’s war chest. When Claire learns Jamie has gone back on his word, the couple are met with dire consequences that will forever change their lives.

Claire is brought to L’Hopital Des Anges where doctors try to save her life and that of her unborn baby. King Louis asks Claire to judge two men accused of practicing the dark arts – one an enemy, one a friend.

Claire and Jamie call upon Jamie’s grandsire, Lord Lovat, in an attempt to elicit support for the Jacobite cause. However, a visiting Colum MacKenzie has other plans, and Lord Lovat’s manipulative machinations ensure that no matter what, his own interests will be served.

Claire and Jamie reunite with the Lallybroch and MacKenzie men as they train for war. Jamie’s power struggles with Dougal and Claire’s personal battle with her memories of WWII weigh upon them, but new, helpful information comes to light when a young Englishman named William Grey pays a surprise visit to their camp.

Jamie relies upon Claire's knowledge of history to lead the Jacobite army into a crucial battle. Claire is reminded of the true cost of war as she attends to the dead and dying.

Claire and the Highlanders head north after the Jacobite leaders decide to halt their march on London. Claire has an unexpected reunion after a band of redcoats makes trouble for the Scots.

Jamie works to divert the Jacobite army away from imminent slaughter. Claire tries to provide comfort to a sick Alex Randall who shares an unusual plan to save the mother of his child.

In the present, Claire reveals the truth to her daughter, Brianna. In the 18th century, Jamie does everything he can to save his loved ones as the Battle of Culloden begins.