Bruce Banner's latest attempt to rid himself of the Hulk is shut down by General Ross and Major Talbot. Now being held in the Gamma Base, Bruce recalls how he became the Incredible Hulk.

On the run from General Ross, Hulk encounters the Gamma Mutant Warriors. But Abomination reappears and captures Bruce. He is taken to The Leader, who wants the power of the Hulk for himself.

Bruce Banner and Rick Jones are in L.A., seeking the help of wealthy industrialist Tony Stark. Iron Man, War Machine and H.O.M.E.R. will have to find a way to cure Bruce of the Hulk before S.H.I.E.L.D. Agent Gabriel Jones arrives.

Ghost Rider is after the Hulk and so it Talbot, who has a deadly new weapon at his disposal.

Bruce is in Canada looking for the help of his old friend, Dr. Walter Lankowski. When he does find him, Bruce learns his deadly secret.

Bruce is visiting his cousin, Jennifer Walters, in Washington D.C. But Doctor Doom attacks and captures them, leaving Jennifer needs a blood transfusion. Only Bruce can donate and Jennifer becomes She-Hulk.

Bruce and She-Hulk seek the help of Reed Richards, but instead find the Thing alone at Four Freedoms Plaza. With the other members of the Fantastic Four on vacation, it's up to the Thing, Hulk and She-Hulk to defeat the Ogress and The Leader's Gamma Warriors.

When a gamma virus outbreak occurs in Chicago, Dr. Donald Blake transforms into the mighty Thor to force the Hulk to Chicago. Bruce has to work with Gargoyle, who released the virus, to find a cure.

Betty encounters the legendary monster, Wendigo. Bruce is unable to save her because Agent Jones and General Ross capture him. Even though he escapes, he is handcuffed to the General, and as much as they hate to admit it, they'll have to work together to save Betty.

Betty and Doc Samson have found a way to seperate Bruce from the Hulk. All they need now is to smuggle the Hulk into the Gamma Base lab where the Nutrient Bath is waiting.

Bruce and the Hulk are now two separate beings, but the Hulk escapes and goes on a destructive rampage. The Leader captures him and has his intellect placed into the Hulk's body, acquiring the power he's craved.

Equipped with exo-armor, Bruce battles the Incredible Hulk in a massive battle in the desert. When it's over, it's discovered they can't exist without each other and are dying. Their only hope is rejoin via the Nutrient Bath, but General Ross' interference will cause it to go horribly wrong.