After returning to the Lawless district seven years after the massacre of his family, Avilio gets reaquanted with an old friend and they both dive into a new way of life.

Avilio has taken the first step towards his revenge. But Serpente's body, which he needs to provide his cover story, has disappeared, casting suspicion on Avilio. Nero orders him to bring back Serpente's body at gunpoint. Meanwhile, Fango is also looking for Serpente. Exactly what did happen in those missing hours?

After the incident with Vanno and Serpente, a war between the Vanetti and Orco families is all but guaranteed. Nero goes on the run with Avilio, where the two learn a great deal about each other's personality and past. But a huge man and his hunting dog are pursuing them.

Avilio and Nero shake off the Orco family's assassin and continue to lie low, until Nero's regular call to Barbero reveals a new development in the conflict: Orco wants peace with the Vanetti family. Still, Barbero suggests that it might not be best for Nero to return to Lawless immediately, and tells Nero and Avilio to meet him at "the Lodge" in two days.

Frate's betrayal has left Nero on the run with the Vanetti family in pursuit. To save the badly injured Tigre, Nero seeks the aid of Fango, who is currently holed up on the Island. In exchange for his help, Nero agrees to bring Don Orco to Fango alive. To that end, Avilio and Nero head for Orco's base of operations, Ottimo Orco.

The Fango family has taken the place of the Orco family. Fango is grateful to Nero and Avilio for their hard work, and asks them to continue to work with him. But Nero is worried that Fango is going to use him and then kill him. It's then that Frate declares war on his brother, and things get to where there's no turning back. Nevertheless, Fio asks Ronaldo to make peace with Nero.

A hard-nosed prohibition agent, Delphy, is installed in Lawless. He claims he will cut out the mafia's power in the city, and begins clamping down on bars that sell bootleg liquor. Naturally, the Vanetti family considers him an unwelcome presence. While keeping one eye on Fango, Nero comes down hard against Defphy, and Avilio stands with him. But another man watches them with complicated feelings about the situation.

The identity of the traitor who leaked information to Fango and tried to kill Nero has been revealed. With Corteo taken into custody, the Vanetti family has been thrown into an uproar. But Corteo stubbornly refuses to confess anything, a fact which will likely lead to his death. Though he won't admit to it, Avilio is unusually shaken by this. And then Cerotto pays him a visit.

Having succeeded Don Vanetti, Nero decides to send a shipment of Lawless Heaven to Don Galassia to make way for the family's expansion. While the rest of the family searches for Corteo, Nero assigns Avilio to the task. He boards a boat to Chicago with his trunk. But where is Corteo? And what was the motivation behind the one who sent him the letter?

Vincent's dream, the Vanetti playhouse, is now complete. Don Galassia and his nephew Strega, have been invited. In public, they are friendly with Nero, but they are the large family that controls Chicago. The playhouse's opening the next day is wreathed in tension. And at last, the day Avilio's been waiting for has arrived.

A violent gunfight erupts at the playhouse. Black smoke arises from explosions on the Island. The Vanetti family is on the brink of destruction, and Avilio has accomplished his revenge. Where does he go from here? And what will Nero do, having lost everything at Avilio's hands?