When Kevin O'Neil, a realtor to the stars, is accused of brutally murdering his beautiful wife Caitlin, he hires the firm of Trott, Nicholson, Tuller & Gaines. Spurred on by the court TV show, American Crime, the media have all but convicted him and are out for blood as is the prosecutor. But the lawyers at TNT&G use state-of-the-art forensic interpretation, jury consultants, mock juries, experts, and masterful media spin to defend Kevin. All techniques may be successful as long as the attorneys can cope with the new evidence that seems to keep turning up.

TNT&G takes the case of a young female college student claiming self-defense in the death of a famous music producer who has a history of abusing women. Soon the attorneys believe they might be defending a cold-blooded murderer because she changes her testimony to explain each new, incriminating piece of evidence that is found.

TNT&G goes to Orange County when a bartender, who is employed at a restaurant co-owned by Ron, is accused of killing a runaway bride. Ron's certainty of a win begins to wane, however, when the team encounters the culture shock of Orange County.

TNT&G takes the case of the unruly daughter of one of Tom's friends after she is accused of murdering her ex-boyfriend at a fancy rehab center. The case is in jeopardy, however, as several lawyers allow personal feelings to affect their decisions.

TNT&G represents a teenaged outcast with a history of antisocial behavior who has been accused of the ritualistic murder of the high school bully.

TNT&G takes the case in a wrongful death suit on behalf of the parents of the girlfriend of a millionaire's son after they are both killed the crash of a small engine plane. The girl's parents believe the son's mother is covering up the reason for the crash.

A media frenzy ensues as TNT&G attempts to prove their client, a dot-com billionaire, did not murder his wife after she disappears from their yacht and is found washed up on the beach half-eaten by sharks.

Tom convinces the TNT&G attorneys to represent the parking attendant in their building after his wife is found shot to death in their mobile home and only the husband's fingerprints are on the murder weapon.

TNT&G takes the case of Ron Trott's former lover who claims she murdered her teenaged son in self-defense.

A man who Luther had successfully prosecuted for murder 15 years earlier when he was the district attorney becomes his client after the man is accused of murdering his landlord.

Luther assists Tom in defending a college student who has been accused of murdering a cab driver. Meantime, a baby has been abandoned in the TNT&G offices, and Ron and Alden must find the mother while the rest of the team are at the annual holiday party.

A babysitter is blamed for the death of a child and forced to confess. Despite the way the confession was obtained it was allowed in the trial.