It is Saturday night and Katie and Sarah race to help a man who has collapsed at home. By midnight, revellers spilling out of bars and clubs start to impact the service as calls flood in of brawls and accidents.

1 hour into the night-shift the control centre is already onto its 3rd cardiac arrest and the 12th stabbing victim of the weekend. Other crews are tied up caring for an alcoholic and an elderly man.

A crew are dispatched to attend to a woman complaining of stomach pains, but she has actually suffered a massive heart attack. Terminal cancer patient Nigel is philosophical about his life.

Jo and Suki are involved in high drama as they take a patient to hospital when a car crashes right in front of them. Call-handlers deal with two suicidal patients. In Birmingham a woman has had her finger bitten off.

The air ambulance is dispatched to a woman struggling to breathe after falling, but the helicopter is soon also needed at a road accident in Staffordshire. Reports of a hanging come in but is the call a hoax?

Justin and Dawn's first call of the day is to a woman whose waters have broken. A drunken man, repeat callers and a woman unable to leave her home all test the crews patience.

Two brothers battling with addiction strikes a personal chord for paramedic Nina.